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Title:

Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Taruttis, Adrian; Morscher, Stefan; Burton, Neal C; Razansky, Daniel; Ntziachristos, Vasilis
Abstract:
The characterization of pharmacokinetic and biodistribution profiles is an essential step in the development process of new candidate drugs or imaging agents. Simultaneously, the assessment of organ function related to the uptake and clearance of drugs is of great importance. To this end, we demonstrate an imaging platform capable of high-rate characterization of the dynamics of fluorescent agents in multiple organs using multispectral optoacoustic tomography (MSOT). A spatial resolution of appr...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
1
Pages contribution:
e30491
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0030491
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22295087
Print-ISSN:
1932-6203
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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