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Title:

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bareyre, Florence M; Garzorz, Natalie; Lang, Claudia; Misgeld, Thomas; Büning, Hildegard; Kerschensteiner, Martin
Abstract:
In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas axons in the CNS fail to regrow. In neurons of the dorsal root ganglia (DRG), which extend branches to both the PNS and CNS, only a PNS lesion but not a CNS lesion induces axonal growth. How this differential growth response is regulated in vivo is only incompletely understood. Here, we combine in vivo time-lapse fluorescence microscopy with genetic manipulations in mice to reveal how the transcription factor...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2011
Journal volume:
108
Journal issue:
15
Pages contribution:
6282-7
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1015239108
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21447717
Print-ISSN:
0027-8424
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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