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Title:

Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Fieni, Francesca; Parkar, Anjum; Misgeld, Thomas; Kerschensteiner, Martin; Lichtman, Jeff W; Pasinelli, Piera; Trotti, Davide
Abstract:
Potassium fluxes integrate mitochondria into cellular activities, controlling their volume homeostasis and structural integrity in many pathophysiological mechanisms. The outer mitochondrial membrane (OMM) is thought to play a passive role in this process because K(+) is believed to equilibrate freely between the cytosol and mitochondrial intermembrane space. By patch clamping mitochondria isolated from the central nervous systems of adult mitoCFP transgenic mice, we discovered the existence of...     »
Journal title abbreviation:
J Biol Chem
Year:
2010
Journal volume:
285
Journal issue:
35
Pages contribution:
27411-7
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M110.131243
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20551319
Print-ISSN:
0021-9258
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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