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Title:

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.

Document type:
Journal Article; Article
Author(s):
Giannakakou, P; Sackett, DL; Kang, YK; Zhan, Z; Buters, JT; Fojo, T; Poruchynsky, MS
Abstract:
Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human ovarian carcinoma cells. Single-step paclitaxel selection with verapamil yielded two clones that are resistant to paclitaxel and collaterally sensitive to vinblastine. The resistant sublines are not paclitaxel-dependent, and resistance remained stable after 3 years of drug-free culture. All cell lines accumulate [3H]paclitaxel...     »
Journal title abbreviation:
J Biol Chem
Year:
1997
Journal volume:
272
Journal issue:
27
Pages contribution:
17118-25
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.272.27.17118
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/9202030
Print-ISSN:
0021-9258
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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