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Titel:

Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells.

Dokumenttyp:
Journal Article
Autor(en):
Quinnan, GV; Yu, XF; Lewis, MG; Zhang, PF; Sutter, G; Silvera, P; Dong, M; Choudhary, A; Sarkis, PT; Bouma, P; Zhang, Z; Montefiori, DC; Vancott, TC; Broder, CC
Abstract:
We studied the capacity of active immunization of rhesus monkeys with HIV-1 envelope protein (Env) to induce primary virus cross-reactive neutralizing antibodies to prevent infection following intravenous challenge with simian-human immunodeficiency virus (SHIV). Monkeys were immunized with the human immunodeficiency type 1 (HIV-1) strain R2 Env. Initially, the Env was expressed in vivo by an alphavirus replicon particle system, and then it was administered as soluble oligomeric gp140. Concurren...     »
Zeitschriftentitel:
J Virol
Jahr:
2005
Band / Volume:
79
Heft / Issue:
6
Seitenangaben Beitrag:
3358-69
Sprache:
eng
Volltext / DOI:
doi:10.1128/JVI.79.6.3358-3369.2005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15731230
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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