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Titel:

Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Bukur, J; Rebmann, V; Grosse-Wilde, H; Luboldt, H; Ruebben, H; Drexler, I; Sutter, G; Huber, C; Seliger, B
Abstract:
The nonclassical HLA-G molecule exhibits a limited tissue distribution and exerts multiple immune regulatory functions. Recent studies indicate that HLA-G expression plays a key role in the induction of immune tolerance and may represent a novel immune escape mechanism of tumor cells. Despite a high frequency of tumor-infiltrating T lymphocytes in renal cell carcinoma (RCC) lesions, outgrowth of tumor cells occurs that might be attributable to abrogation-efficient antitumor responses. To delinea...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2003
Band / Volume:
63
Heft / Issue:
14
Seitenangaben Beitrag:
4107-11
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12874014
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Virologie
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