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Title:

Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357.

Document type:
Journal Article
Author(s):
Armeanu, S; Pathil, A; Venturelli, S; Mascagni, P; Weiss, TS; Göttlicher, M; Gregor, M; Lauer, UM; Bitzer, M
Abstract:
BACKGROUND/AIMS: Due to a particular resistance against conventional chemotherapeutics, palliative treatment of hepatocellular carcinomas (HCC) is highly ineffective. Recent demonstration of both proliferation-inhibition and apoptosis of hepatoma cells by a histone deacetylase inhibitor (HDAC-I) treatment opens up a promising new approach. However, little is known about tumor cell death mechanisms and HDAC-I influences on healthy hepatocytes. METHODS: HDAC-I substances with favourable in vivo pr...     »
Journal title abbreviation:
J Hepatol
Year:
2005
Journal volume:
42
Journal issue:
2
Pages contribution:
210-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2004.10.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15664246
Print-ISSN:
0168-8278
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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