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Titel:

TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.

Dokumenttyp:
Journal Article
Autor(en):
Weiss, C; Faust, D; Dürk, H; Kolluri, SK; Pelzer, A; Schneider, S; Dietrich, C; Oesch, F; Göttlicher, M
Abstract:
The aryl hydrocarbon receptor (AhR) has a fundamental role during postnatal liver development and is essential for mediating dioxin toxicity. However, the genetic programs mediating, both, the toxic and physiological effects downstream of the transcription factor AhR are in major parts unknown. We have identified the proto-oncogene c-jun as a novel target gene of AhR. Induction of c-jun depends on activation of p38-mitogen-activated protein kinase (MAPK) by an AhR-dependent mechanism. None of th...     »
Zeitschriftentitel:
Oncogene
Jahr:
2005
Band / Volume:
24
Heft / Issue:
31
Seitenangaben Beitrag:
4975-83
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1208679
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15897893
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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