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Title:

Specific and redundant functions of histone deacetylases in regulation of cell cycle and apoptosis.

Document type:
Journal Article
Author(s):
Zhu, P; Huber, E; Kiefer, F; Göttlicher, M
Abstract:
Inappropriate control of expression of genetic information is the cause of many forms of cancer. Aberrant transcriptional repression by recruitment of histone deacetylases (HDACs) is a key step in pathogenesis of myeloid leukemia. We recently reported that development of colonic cancer involves alterations in the transcriptional repression machinery by increased expression of HDAC2 upon loss of the APC tumor suppressor. Increased expression of HDAC2 is essential for prevention of apoptosis of HT...     »
Journal title abbreviation:
Cell Cycle
Year:
2004
Journal volume:
3
Journal issue:
10
Pages contribution:
1240-2
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15477762
Print-ISSN:
1538-4101
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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