User: Guest  Login
More Searchfields
Simple search
Title:

Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases.

Document type:
Journal Article; Review
Author(s):
Göttlicher, M
Abstract:
Fusion proteins encoded by several types of chromosomal translocations in promyelocytic leukemia can serve as aberrant transcriptional repressors relying on recruitment of histonedeacetylases (HDACs) into DNA-associated multi-protein complexes. Thus, inappropriate modulation of chromatin structure by HDACs and subsequently repression of gene expression that is critical for myeloid differentiation appear to be major factors in the development of the disease. They identify inhibitors of HDACs as p...     »
Journal title abbreviation:
Ann Hematol
Year:
2004
Journal volume:
83 Suppl 1
Pages contribution:
S91-2
Language:
eng
Fulltext / DOI:
doi:10.1007/s00277-004-0850-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15124690
Print-ISSN:
0939-5555
TUM Institution:
Institut für Toxikologie und Umwelthygiene
 BibTeX