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Titel:

A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters.

Dokumenttyp:
Journal Article
Autor(en):
Kassel, O; Schneider, S; Heilbock, C; Litfin, M; Göttlicher, M; Herrlich, P
Abstract:
Glucocorticoid receptor (GR)-mediated transrepression of the transcription factors AP-1 and NF-kappaB, responsible for most of the anti-inflammatory effects of glucocorticoids, is initiated by the tethering of GR to the promoters of target genes. We report that this tethering is mediated by a nuclear isoform of the focal adhesion LIM domain protein Trip6. Trip6 functions as a coactivator for both AP-1 and NF-kappaB. As shown by chromatin immunoprecipitation, Trip6 is recruited to the promoters o...     »
Zeitschriftentitel:
Genes Dev
Jahr:
2004
Band / Volume:
18
Heft / Issue:
20
Seitenangaben Beitrag:
2518-28
Sprache:
eng
Volltext / DOI:
doi:10.1101/gad.322404
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15489293
Print-ISSN:
0890-9369
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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