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Titel:

UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation.

Dokumenttyp:
Journal Article
Autor(en):
Gulati, P; Markova, B; Göttlicher, M; Böhmer, FD; Herrlich, PA
Abstract:
UV irradiation causes inflammatory and proliferative cellular responses. We have proposed previously that these effects are, to a large extent, caused by the ligand-independent activation of several receptor tyrosine kinases due to the inactivation of their negative control elements, the protein tyrosine phosphatases (PTPs). We examined the mechanism of this inactivation and found that, in addition to reversible oxidation of PTPs, UV triggers a novel mechanism: induced degradation of PTPs by cal...     »
Zeitschriftentitel:
EMBO Rep
Jahr:
2004
Band / Volume:
5
Heft / Issue:
8
Seitenangaben Beitrag:
812-7
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.embor.7400190
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15247926
Print-ISSN:
1469-221X
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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