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Title:

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.

Document type:
Journal Article
Author(s):
Krämer, OH; Zhu, P; Ostendorff, HP; Golebiewski, M; Tiefenbach, J; Peters, MA; Brill, B; Groner, B; Bach, I; Heinzel, T; Göttlicher, M
Abstract:
Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient and well-tolerated drugs. We show that HDAC2 undergoes basal turnover by the ubiquitin-proteasome pathway. Valproic acid (VPA), in addition to selectively inhibiting the catalytic activity of class I...     »
Journal title abbreviation:
EMBO J
Year:
2003
Journal volume:
22
Journal issue:
13
Pages contribution:
3411-20
Language:
eng
Fulltext / DOI:
doi:10.1093/emboj/cdg315
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12840003
Print-ISSN:
0261-4189
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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