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Titel:

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.

Dokumenttyp:
Journal Article
Autor(en):
Krämer, OH; Zhu, P; Ostendorff, HP; Golebiewski, M; Tiefenbach, J; Peters, MA; Brill, B; Groner, B; Bach, I; Heinzel, T; Göttlicher, M
Abstract:
Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient and well-tolerated drugs. We show that HDAC2 undergoes basal turnover by the ubiquitin-proteasome pathway. Valproic acid (VPA), in addition to selectively inhibiting the catalytic activity of class I...     »
Zeitschriftentitel:
EMBO J
Jahr:
2003
Band / Volume:
22
Heft / Issue:
13
Seitenangaben Beitrag:
3411-20
Sprache:
eng
Volltext / DOI:
doi:10.1093/emboj/cdg315
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12840003
Print-ISSN:
0261-4189
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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