Benutzer: Gast  Login
Titel:

Bradycardic and proarrhythmic properties of sinus node inhibitors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Stieber, J; Wieland, K; Stöckl, G; Ludwig, A; Hofmann, F
Abstract:
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels. We tested the potential subtype-specificity of the sinus node inhibitors cilobradine, ivabradine, and zatebradine using cloned HCN channels. All three substances blocked the slow inward current through human HCN1, HCN2, HCN3, and HCN4 channels. There was n...     »
Zeitschriftentitel:
Mol Pharmacol
Jahr:
2006
Band / Volume:
69
Heft / Issue:
4
Seitenangaben Beitrag:
1328-37
Sprache:
eng
Volltext / DOI:
doi:10.1124/mol.105.020701
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16387796
Print-ISSN:
0026-895X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
 BibTeX