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Title:

Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.

Document type:
Journal Article; Article
Author(s):
Moosmang, S; Haider, N; Bruderl, B; Welling, A; Hofmann, F
Abstract:
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca2+ channel Cav1.2 (Cav1.2SMAKO mice) to genetically dissect the effects of mibefradil on T- and L-type Ca2+ cha...     »
Journal title abbreviation:
Circ Res
Year:
2006
Journal volume:
98
Journal issue:
1
Pages contribution:
105-10
Language:
eng
Fulltext / DOI:
doi:10.1161/01.RES.0000197851.11031.9c
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16306443
Print-ISSN:
0009-7330
TUM Institution:
Institut für Pharmakologie und Toxikologie
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