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Titel:

The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes.

Dokumenttyp:
Journal Article; Article
Autor(en):
Gomes, B; Savignac, M; Cabral, MD; Paulet, P; Moreau, M; Leclerc, C; Feil, R; Hofmann, F; Guéry, JC; Dietrich, G; Pelletier, L
Abstract:
Th2 lymphocytes differ from other CD4+ T lymphocytes not only by their effector tasks but also by their T cell receptor (TCR)-dependent signaling pathways. We previously showed that dihydropyridine receptors (DHPR) involved in TCR-induced calcium inflow were selectively expressed in Th2 cells. In this report, we studied whether cGMP-dependent protein kinase G (PKG) activation was implicated in the regulation of DHPR-dependent calcium response and cytokine production in Th2 lymphocytes. The contr...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2006
Band / Volume:
281
Heft / Issue:
18
Seitenangaben Beitrag:
12421-7
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M510653200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16533816
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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