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Titel:

Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Lee, TS; Karl, R; Moosmang, S; Lenhardt, P; Klugbauer, N; Hofmann, F; Kleppisch, T; Welling, A
Abstract:
Calcium-dependent facilitation of L-type calcium channels has been reported to depend on the function of calmodulin kinase II. In contrast, the mechanism for voltage-dependent facilitation is not clear. In HEK 293 cells expressing Ca(v)1.2, Ca(v)beta2a, and calmodulin kinase II, the calcium current measured at +30 mV was facilitated up to 1.5-fold by a 200-ms-long prepulse to +160 mV. This voltage-dependent facilitation was prevented by the calmodulin kinase II inhibitors KN93 and the autocamtid...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2006
Band / Volume:
281
Heft / Issue:
35
Seitenangaben Beitrag:
25560-7
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M508661200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16820363
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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