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Title:

Endothelium mediated aortic relaxation and blood pressure lowering effect of a procyanidin rich fraction of the stembark extracts of Erythrophleum suaveolens

Document type:
Article
Author(s):
Kamanyi, A; Dongmo, AB; Salah, MA; Jatsa, H; Wagner, H; Vierling, W; Bopelet, M
Abstract:
A procyanidin-rich fraction of the stembark extracts of Erythrophleum suaveolens induced significant dose-dependent (0.1-100 mug/ml) relaxation of the guinea pig and rat aortic ring segments precontracted with noradrenaline (10 muM) and potassium chloride (KCl, 30 mM). However, the extract produced more significant relaxation in aortic rings with endothelium intact (+E) than in those without endothelium (-E). The plant extract produced a relaxation effect of 54.35 +/- 3.53% in rat aortic rings i...     »
Journal title abbreviation:
Pharm Biol
Year:
2003
Journal volume:
41
Journal issue:
1
Pages contribution:
62-67
Language:
eng
Print-ISSN:
0553-9323
TUM Institution:
Institut für Pharmakologie und Toxikologie
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