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Title:

Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma.

Document type:
Journal Article
Author(s):
Kappler, R; Hess, I; Schlegel, J; Hahn, H
Abstract:
Medulloblastoma (MB) is a highly malignant embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of MBs occur sporadically, this tumor is also associated with familial cancer syndromes including the nevoid basal cell carcinoma or Gorlin syndrome. Mutations in the tumor suppressor gene PATCHED 1 (PTCH1) have been described in both familial and sporadic cases and inactivation of one Patched 1 (Ptch1) allele in mice promotes development of MB. In ord...     »
Journal title abbreviation:
Int J Oncol
Year:
2004
Journal volume:
25
Journal issue:
1
Pages contribution:
113-20
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15201996
Print-ISSN:
1019-6439
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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