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Titel:

Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).

Dokumenttyp:
Journal Article; Article
Autor(en):
Welling, A; Hofmann, F; Wegener, JW
Abstract:
Phosphatidylinositol 3-kinase (PI3-K) is involved in physiological processes of cellular proliferation and inflammation and, as postulated recently, in the regulation of L-type Ca(2+) channels. The latter conclusion arose in part from the inhibitory action of the compound 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), which has been established as a selective PI3-K inhibitor (IC(50) = 1.4 microM). Herein we show, however, that LY294002 and an inhibitor of protein kinase C (PKC), 2-...     »
Zeitschriftentitel:
Mol Pharmacol
Jahr:
2005
Band / Volume:
67
Heft / Issue:
2
Seitenangaben Beitrag:
541-4
Sprache:
eng
Volltext / DOI:
doi:10.1124/mol.104.006049
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15537868
Print-ISSN:
0026-895X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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