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Dokumenttyp:
Journal Article; Review; Article
Autor(en):
Feil, R; Feil, S; Hofmann, F
Titel:
A heretical view on the role of NO and cGMP in vascular proliferative diseases.
Abstract:
Endogenous nitric oxide (NO), and possibly NO-releasing drugs, can both inhibit and promote vascular proliferative disorders, such as atherosclerosis and restenosis. The cell types and signaling pathways that mediate these opposing effects are controversial. It is widely assumed that the NO-mediated synthesis of the second messenger cGMP and the activation of cGMP-dependent protein kinase type I (cGKI) inhibits the proliferation of vascular smooth muscle cells and, thus, vascular remodeling. How...     »
Zeitschriftentitel:
Trends Mol Med
Jahr:
2005
Band / Volume:
11
Heft / Issue:
2
Seitenangaben Beitrag:
71-5
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.molmed.2004.12.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15694869
Print-ISSN:
1471-4914
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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