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Title:

cGMP-dependent protein kinases in drug discovery.

Document type:
Journal Article; Review; Review
Author(s):
Schlossmann, J; Hofmann, F
Abstract:
Cyclic guanosine-3', 5'-monophosphate (cGMP)-dependent protein kinases (cGKs) are key enzymes of nitric oxide-cGMP and natriuretic peptide signalling cascades. These kinases mediate most of the effects of cGMP-elevating drugs, such as nitrates and phosphodiesterase inhibitors. cGKs modulate smooth muscle relaxation (e.g. the vasculature, gastrointestinal tract, bladder and penile), platelet aggregation, renin release, intestinal secretion, learning and memory. Furthermore, several cGK substrates...     »
Journal title abbreviation:
Drug Discov Today
Year:
2005
Journal volume:
10
Journal issue:
9
Pages contribution:
627-34
Language:
eng
Fulltext / DOI:
doi:10.1016/S1359-6446(05)03406-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15894227
Print-ISSN:
1359-6446
TUM Institution:
Institut für Pharmakologie und Toxikologie
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