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Titel:

cGMP-dependent protein kinases in drug discovery.

Dokumenttyp:
Journal Article; Review; Review
Autor(en):
Schlossmann, J; Hofmann, F
Abstract:
Cyclic guanosine-3', 5'-monophosphate (cGMP)-dependent protein kinases (cGKs) are key enzymes of nitric oxide-cGMP and natriuretic peptide signalling cascades. These kinases mediate most of the effects of cGMP-elevating drugs, such as nitrates and phosphodiesterase inhibitors. cGKs modulate smooth muscle relaxation (e.g. the vasculature, gastrointestinal tract, bladder and penile), platelet aggregation, renin release, intestinal secretion, learning and memory. Furthermore, several cGK substrates...     »
Zeitschriftentitel:
Drug Discov Today
Jahr:
2005
Band / Volume:
10
Heft / Issue:
9
Seitenangaben Beitrag:
627-34
Sprache:
eng
Volltext / DOI:
doi:10.1016/S1359-6446(05)03406-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15894227
Print-ISSN:
1359-6446
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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