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Titel:

Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Osterloh, P; Linkemann, K; Tenzer, S; Rammensee, HG; Radsak, MP; Busch, DH; Schild, H
Abstract:
Differences in the cleavage specificities of constitutive proteasomes and immunoproteasomes significantly affect the generation of MHC class I ligands and therefore the activation of CD8-positive T cells. Based on these findings, we investigated whether proteasomal specificity also influences CD8-positive T cells during thymic selection by peptides derived from self proteins. We find that one of the self peptides responsible for positive selection of ovalbumin-specific OT-1 T cells, which is der...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2006
Band / Volume:
103
Heft / Issue:
13
Seitenangaben Beitrag:
5042-7
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.0509256103
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16549793
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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