User: Guest  Login
Title:

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

Document type:
Journal Article
Author(s):
Herbert, DR; Hölscher, C; Mohrs, M; Arendse, B; Schwegmann, A; Radwanska, M; Leeto, M; Kirsch, R; Hall, P; Mossmann, H; Claussen, B; Förster, I; Brombacher, F
Abstract:
Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by T(H)2 development and goblet cell hyperplasia. In contrast, LysM(Cre)IL-4Ralpha(-/flox) mice were extremely susceptible to Schistosoma mansoni infection with 100% mortality during...     »
Journal title abbreviation:
Immunity
Year:
2004
Journal volume:
20
Journal issue:
5
Pages contribution:
623-35
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15142530
Print-ISSN:
1074-7613
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX