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Titel:

HIF-1alpha is essential for myeloid cell-mediated inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Cramer, T; Yamanishi, Y; Clausen, BE; Förster, I; Pawlinski, R; Mackman, N; Haase, VH; Jaenisch, R; Corr, M; Nizet, V; Firestein, GS; Gerber, HP; Ferrara, N; Johnson, RS
Abstract:
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts of the hypoxia responsive transcription factor HIF-1alpha, its negative regulator VHL, and a known downstream target, VEGF. We find that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a mechanism independent of VEGF. Loss of VHL leads to a large increa...     »
Zeitschriftentitel:
Cell
Jahr:
2003
Band / Volume:
112
Heft / Issue:
5
Seitenangaben Beitrag:
645-57
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12628185
Print-ISSN:
0092-8674
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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