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Title:

The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.

Document type:
Journal Article
Author(s):
Heil, F; Ahmad-Nejad, P; Hemmi, H; Hochrein, H; Ampenberger, F; Gellert, T; Dietrich, H; Lipford, G; Takeda, K; Akira, S; Wagner, H; Bauer, S
Abstract:
Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) acts as synthetic adjuvant in anti-tumor responses. Here we first demonstrate that loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. TLR7- and MyD88-deficient immune cells fail to proliferate or produce cytokines in response to loxoribine, and genetic complementation of TLR7-deficient cells with murine or human TLR7 confers responsiveness. Subsequently we show t...     »
Journal title abbreviation:
Eur J Immunol
Year:
2003
Journal volume:
33
Journal issue:
11
Pages contribution:
2987-97
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200324238
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14579267
Print-ISSN:
0014-2980
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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