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Title:

Role of endocytosis in cellular uptake of sex steroids.

Document type:
Journal Article; Article
Author(s):
Hammes, A; Andreassen, TK; Spoelgen, R; Raila, J; Hübner, N; Schulz, H; Metzger, J; Schweigert, FJ; Luppa, PB; Nykjaer, A; Willnow, TE
Abstract:
Androgens and estrogens are transported bound to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex steroids inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. In line with this function, lack of receptor expression in megal...     »
Journal title abbreviation:
Cell
Year:
2005
Journal volume:
122
Journal issue:
5
Pages contribution:
751-62
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2005.06.032
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16143106
Print-ISSN:
0092-8674
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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