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Titel:

Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.

Dokumenttyp:
Journal Article
Autor(en):
Olszewska, W; Suezer, Y; Sutter, G; Openshaw, PJ
Abstract:
Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. MVA-F or MVA-G vaccination enhanced weight loss during RSV challenge, but did not show the lung eosinophilia seen after FI-RSV vaccination. FI-RSV induced a stronger total RSV IgG re...     »
Zeitschriftentitel:
Vaccine
Jahr:
2004
Band / Volume:
23
Heft / Issue:
2
Seitenangaben Beitrag:
215-21
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.vaccine.2004.05.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15531040
Print-ISSN:
0264-410X
TUM Einrichtung:
Institut für Virologie
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