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Titel:

Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.

Dokumenttyp:
Journal Article
Autor(en):
Koopman, G; Mortier, D; Hofman, S; Niphuis, H; Fagrouch, Z; Norley, S; Sutter, G; Liljeström, P; Heeney, JL
Abstract:
Candidate human immunodeficiency virus (HIV) vaccine strategies that induce strong cellular immune responses protect rhesus macaques that are infected with recombinant simian/human immunodeficiency virus SHIV89.6p from acute CD4+ T-cell loss and delay progression to AIDS. However, similar strategies have not proven as efficacious in the simian immunodeficiency virus (SIV)mac model of AIDS, an infection that causes a slow, steady loss of CD4+ T-cell function and numbers in rhesus macaques similar...     »
Zeitschriftentitel:
J Gen Virol
Jahr:
2004
Band / Volume:
85
Heft / Issue:
Pt 10
Seitenangaben Beitrag:
2915-24
Sprache:
eng
Volltext / DOI:
doi:10.1099/vir.0.80226-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15448353
Print-ISSN:
0022-1317
TUM Einrichtung:
Institut für Virologie
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