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Titel:

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

Dokumenttyp:
Journal Article
Autor(en):
Herrmann, F; Lehr, HA; Drexler, I; Sutter, G; Hengstler, J; Wollscheid, U; Seliger, B
Abstract:
Because of its amplification and/or overexpression in many human tumors, the HER-2/neu proto-oncogene represents an attractive target for T-cell-mediated vaccination strategies. However, overexpression of oncogenes is often associated with defective expression of components of the MHC class I antigen-processing machinery (APM), thereby resulting in an immune escape phenotype of oncogene-transformed cells. To determine whether HER-2/neu influences the MHC class I antigen-processing pathway, the e...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2004
Band / Volume:
64
Heft / Issue:
1
Seitenangaben Beitrag:
215-20
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14729627
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Virologie
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