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Titel:

Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen.

Dokumenttyp:
Journal Article
Autor(en):
Mäkitalo, B; Lundholm, P; Hinkula, J; Nilsson, C; Karlén, K; Mörner, A; Sutter, G; Erfle, V; Heeney, JL; Wahren, B; Biberfeld, G; Thorstensson, R
Abstract:
The immunogenicity and protective efficacy of a DNA and recombinant modified vaccinia Ankara (MVA) vaccine administered by two different routes were investigated. DNA expressing HIV-1 IIIB env, gag, RT, rev, tat and nef, and MVA expressing HIV-1 IIIB nef, tat and rev and simian immunodeficiency virus (SIV) macJ5 gag/pol and vaccinia HIV-1 env, were used as immunogens. Four cynomolgus macaques received DNA intramuscularly (i.m.) at month 0 and intrarectally (i.r.) and intra-orally (i.o.) at 2 mon...     »
Zeitschriftentitel:
J Gen Virol
Jahr:
2004
Band / Volume:
85
Heft / Issue:
Pt 8
Seitenangaben Beitrag:
2407-19
Sprache:
eng
Volltext / DOI:
doi:10.1099/vir.0.79869-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15269383
Print-ISSN:
0022-1317
TUM Einrichtung:
Institut für Virologie
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