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Titel:

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

Dokumenttyp:
Journal Article; Article
Autor(en):
Polymenidou, M; Heppner, FL; Pellicioli, EC; Urich, E; Miele, G; Braun, N; Wopfner, F; Schätzl, HM; Becher, B; Aguzzi, A
Abstract:
Prion diseases are characterized by the deposition of an abnormal form (termed PrP(Sc)) of the cellular prion protein (PrP(C)). Because antibodies to PrP(C) can antagonize deposition of PrP(Sc) in cultured cells and mice, they may be useful for anti-prion therapy. However, induction of protective anti-prion immune responses in WT animals may be hindered by host tolerance. Here, we studied the cellular and molecular basis of tolerance to PrP(C). Immunization of Prnp(o/o) mice with bacterially exp...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2004
Band / Volume:
101 Suppl
Seitenangaben Beitrag:
14670-6
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.0404772101
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15292505
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Virologie
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