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Titel:

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

Dokumenttyp:
Journal Article; Article
Autor(en):
Tegeder, I; Del Turco, D; Schmidtko, A; Sausbier, M; Feil, R; Hofmann, F; Deller, T; Ruth, P; Geisslinger, G
Abstract:
cGMP-dependent protein kinase I (PKG-I) has been suggested to contribute to the facilitation of nociceptive transmission in the spinal cord presumably by acting as a downstream target of nitric oxide. However, PKG-I activators caused conflicting effects on nociceptive behavior. In the present study we used PKG-I(-/-) mice to further assess the role of PKG-I in nociception. PKG-I deficiency was associated with reduced nociceptive behavior in the formalin assay and zymosan-induced paw inflammation...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2004
Band / Volume:
101
Heft / Issue:
9
Seitenangaben Beitrag:
3253-7
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.0304076101
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14973199
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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