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Titel:

GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase.

Dokumenttyp:
Journal Article; Article
Autor(en):
Marshall, SJ; Senis, YA; Auger, JM; Feil, R; Hofmann, F; Salmon, G; Peterson, JT; Burslem, F; Watson, SP
Abstract:
Glycoprotein Ib-IX-V (GPIb-IX-V) mediates platelet tethering to von Willebrand factor (VWF), recruiting platelets into the thrombus, and activates integrin alphaIIbbeta3 through a pathway that is dependent on Src kinases. In addition, recent reports indicate that activation of alphaIIbbeta3 by VWF is dependent on protein kinase G (PKG) and mitogen-activated protein (MAP) kinases. The present study compares the importance of these signaling pathways in the activation of alphaIIbbeta3 by GPIb-IX-V...     »
Zeitschriftentitel:
Blood
Jahr:
2004
Band / Volume:
103
Heft / Issue:
7
Seitenangaben Beitrag:
2601-9
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2003-09-3319
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14684423
Print-ISSN:
0006-4971
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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