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Title:

Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.

Document type:
Journal Article; Article
Author(s):
Werner, C; Raivich, G; Cowen, M; Strekalova, T; Sillaber, I; Buters, JT; Spanagel, R; Hofmann, F
Abstract:
Cyclic GMP is a second messenger for nitric oxide (NO) that acts as a mediator for many different physiological functions. The cGMP-dependent protein kinases (cGKs) mediate cellular signalling induced by NO and cGMP. Here, we explored the localization of cGMP-dependent protein kinase type II (cGKII) in the mouse brain. In situ hybridization revealed high levels of cGKII mRNA in cerebral cortex, thalamic nuclei, hypothalamic nuclei, and in several basal forebrain regions including medial septum,...     »
Journal title abbreviation:
Eur J Neurosci
Year:
2004
Journal volume:
20
Journal issue:
12
Pages contribution:
3498-506
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1460-9568.2004.03793.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15610182
Print-ISSN:
0953-816X
TUM Institution:
Institut für Pharmakologie und Toxikologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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