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Titel:

Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.

Dokumenttyp:
Journal Article
Autor(en):
Ritz, U; Drexler, I; Sutter, D; Abele, R; Huber, C; Seliger, B
Abstract:
The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance regulator and the functional properties of selective amino acids in these ABC transporters postulated that the glutamic acid at position 263 and the phenylalanine at position 265 of the TAP1 subunit could affect peptide transporter function. To define the role of both amino acids, TAP1 mutants containing a deletion or a substi...     »
Zeitschriftentitel:
J Immunol
Jahr:
2003
Band / Volume:
170
Heft / Issue:
2
Seitenangaben Beitrag:
941-6
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12517960
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Virologie
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