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Dokumenttyp:
Journal Article
Autor(en):
Drexler, I; Staib, C; Kastenmuller, W; Stevanovi?, S; Schmidt, B; Lemonnier, FA; Rammensee, HG; Busch, DH; Bernhard, H; Erfle, V; Sutter, G
Titel:
Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.
Abstract:
Despite worldwide eradication of naturally occurring variola virus, smallpox remains a potential threat to both civilian and military populations. New, safe smallpox vaccines are being developed, and there is an urgent need for methods to evaluate vaccine efficacy after immunization. Here we report the identification of an immunodominant HLA-A*0201-restricted epitope that is recognized by cytotoxic CD8(+) T cells and conserved among Orthopoxvirus species including variola virus. This finding has...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2003
Band / Volume:
100
Heft / Issue:
1
Seitenangaben Beitrag:
217-22
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.262668999
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12518065
Print-ISSN:
0027-8424
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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