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Titel:

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.

Dokumenttyp:
Journal Article; Article
Autor(en):
Binder, EB; Salyakina, D; Lichtner, P; Wochnik, GM; Ising, M; Pütz, B; Papiol, S; Seaman, S; Lucae, S; Kohli, MA; Nickel, T; Künzel, HE; Fuchs, B; Majer, M; Pfennig, A; Kern, N; Brunner, J; Modell, S; Baghai, T; Deiml, T; Zill, P; Bondy, B; Rupprecht, R; Messer, T; Köhnlein, O; Dabitz, H; Brückl, T; Muller, N; Pfister, H; Lieb, R; Mueller, JC; Lõhmussaar, E; Strom, TM; Bettecken, T; Meitinger, T; Uhr, M; Rein, T; Holsboer, F; Müller-Myhsok, B
Abstract:
The stress hormone-regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we genotyped single-nucleotide polymorphisms in eight of these genes in depressed individuals and matched controls. We found significant associations of response to antidepressants and the recurrence of depre...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2004
Band / Volume:
36
Heft / Issue:
12
Seitenangaben Beitrag:
1319-25
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng1479
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15565110
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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