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Title:

HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lehmann, MH; Masanetz, S; Kramer, S; Erfle, V
Abstract:
HIV-associated dementia (HAD) correlates with infiltration of monocytes into the brain. The accessory HIV-1 negative factor (Nef) protein, which modulates several signaling pathways, is constitutively present in persistently infected astroctyes. We demonstrated that monocytes responded with chemotaxis when subjected to cell culture supernatants of nef-expressing astrocytic U251MG cells. Using a protein array, we identified CC chemokine ligand 2/monocyte chemotactic protein-1 (CCL2/MCP-1) as a po...     »
Journal title abbreviation:
J Cell Sci
Year:
2006
Journal volume:
119
Journal issue:
Pt 21
Pages contribution:
4520-30
Language:
eng
Fulltext / DOI:
doi:10.1242/jcs.03231
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17046994
Print-ISSN:
0021-9533
TUM Institution:
Institut für Virologie
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