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Titel:

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wolff, H; Hadian, K; Ziegler, M; Weierich, C; Kramer-Hämmerle, S; Kleinschmidt, A; Erfle, V; Brack-Werner, R
Abstract:
The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay,...     »
Zeitschriftentitel:
Exp Cell Res
Jahr:
2006
Band / Volume:
312
Heft / Issue:
4
Seitenangaben Beitrag:
443-56
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.yexcr.2005.11.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16368434
Print-ISSN:
0014-4827
TUM Einrichtung:
Institut für Virologie
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