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Title:

Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ishikawa, K; Kudo, Y; Nishida, N; Suemoto, T; Sawada, T; Iwaki, T; Doh-ura, K
Abstract:
Recent prevalence of acquired forms of transmissible spongiform encephalopathies (TSEs) has urged the development of early diagnostic measures as well as therapeutic interventions. To extend our previous findings on the value of amyloid imaging probes for these purposes, styrylbenzoazole derivatives with better permeability of blood-brain barrier (BBB) were developed and analyzed in this study. The new styrylbenzoazole compounds clearly labeled prion protein (PrP) plaques in brain specimens from...     »
Journal title abbreviation:
J Neurochem
Year:
2006
Journal volume:
99
Journal issue:
1
Pages contribution:
198-205
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1471-4159.2006.04035.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16987247
Print-ISSN:
0022-3042
TUM Institution:
Institut für Virologie
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