Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lehmann, MH; Masanetz, S; Kramer, S; Erfle, V
Abstract:
HIV-associated dementia (HAD) correlates with infiltration of monocytes into the brain. The accessory HIV-1 negative factor (Nef) protein, which modulates several signaling pathways, is constitutively present in persistently infected astroctyes. We demonstrated that monocytes responded with chemotaxis when subjected to cell culture supernatants of nef-expressing astrocytic U251MG cells. Using a protein array, we identified CC chemokine ligand 2/monocyte chemotactic protein-1 (CCL2/MCP-1) as a po...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2006
Band / Volume:
119
Heft / Issue:
Pt 21
Seitenangaben Beitrag:
4520-30
Sprache:
eng
Volltext / DOI:
doi:10.1242/jcs.03231
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17046994
Print-ISSN:
0021-9533
TUM Einrichtung:
Institut für Virologie
 BibTeX