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Titel:

Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss.

Dokumenttyp:
Journal Article
Autor(en):
Scherer, EQ; Arnold, W; Wangemann, P
Abstract:
BACKGROUND: Vasospasm of the spiral modiolar artery (SMA) may cause ischemic stroke of the inner ear. Endothelin-1 (ET-1) induces a strong, long-lasting constriction of the SMA by increasing contractile apparatus Ca2+ sensitivity via Rho-kinase. We therefore tested several Rho-kinase inhibitors and a cell-permeable analogue of cAMP (dbcAMP) for their ability to reverse ET-1-induced constriction and Ca2+-sensitization. METHODS: The present study employed SMA isolated from gerbil temporal bones. C...     »
Zeitschriftentitel:
BMC Ear Nose Throat Disord
Jahr:
2005
Band / Volume:
5
Seitenangaben Beitrag:
10
Sprache:
eng
Volltext / DOI:
doi:10.1186/1472-6815-5-10
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16316469
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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