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Titel:

Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells.

Dokumenttyp:
Journal Article
Autor(en):
BelAiba, RS; Djordjevic, T; Bonello, S; Flügel, D; Hess, J; Kietzmann, T; Gorlach, A
Abstract:
Pulmonary hypertension and vascular remodeling processes are associated with oxidative stress, hypoxia and enhanced levels of thrombin and vascular endothelial growth factor (VEGF). The hypoxia-inducible transcription factor HIF regulates the expression of VEGF under hypoxia. The HIF pathway is also activated by thrombin or CoCl2, likely via reactive oxygen species (ROS). In this study we investigated whether the redox-modifying enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX) an...     »
Zeitschriftentitel:
Biol Chem
Jahr:
2004
Band / Volume:
385
Heft / Issue:
3-4
Seitenangaben Beitrag:
249-57
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15134338
Print-ISSN:
1431-6730
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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