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Title:

Lack of RUNX3 regulation in human gastric cancer.

Document type:
Journal Article
Author(s):
Friedrich, MJ; Rad, R; Langer, R; Voland, P; Hoefler, H; Schmid, RM; Prinz, C; Gerhard, M
Abstract:
It has been proposed that the transcription factor RUNX3 is the product of a gastric tumour suppressor gene. We examined RUNX3 expression in gastric biopsies from 105 patients with different histological presentations. Surprisingly, immunohistochemical staining detected RUNX3 protein expression only in infiltrating leukocytes but not in the gastric epithelium. Using laser capture microdissection and quantitative reverse transcription-polymerase chain reaction, we confirmed that the level of RUNX...     »
Journal title abbreviation:
J Pathol
Year:
2006
Journal volume:
210
Journal issue:
2
Pages contribution:
141-6
Language:
eng
Fulltext / DOI:
doi:10.1002/path.2042
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16917803
Print-ISSN:
0022-3417
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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