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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Beaufort, N; Debela, M; Creutzburg, S; Kellermann, J; Bode, W; Schmitt, M; Pidard, D; Magdolen, V
Titel:
Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).
Abstract:
The plasminogen activation system is involved in cancer progression and metastasis. Among other proteolytic factors, it includes the serine protease urokinase-type plasminogen activator (uPA) and its three-domain (D1D2D3) receptor uPAR (CD87), which focuses plasminogen activation to the cell surface. The function of uPAR is regulated in part through shedding of domain D1 by proteases, e.g., uPA itself or plasmin. Human tissue kallikrein 4 (hK4), which is highly expressed in prostate and ovarian...     »
Zeitschriftentitel:
Biol Chem
Jahr:
2006
Band / Volume:
387
Heft / Issue:
2
Seitenangaben Beitrag:
217-22
Sprache:
eng
Volltext / DOI:
doi:10.1515/BC.2006.029
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16497155
Print-ISSN:
1431-6730
TUM Einrichtung:
Frauenklinik und Poliklinik
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