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Titel:

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8; 21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.

Dokumenttyp:
Journal Article; Article
Autor(en):
Elsässer, A; Franzen, M; Kohlmann, A; Weisser, M; Schnittger, S; Schoch, C; Reddy, VA; Burel, S; Zhang, DE; Ueffing, M; Tenen, DG; Hiddemann, W; Behre, G
Abstract:
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun N-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression and the role of the JNK signaling pathway have not been investigated in primary acute myeloid leukemia (AML) cells with frequently observed balanced rearrangements such as t(8; 21). In the present study, we report elevated c-jun mRNA expression in AML patient bone marrow cells with t(8; 21),...     »
Zeitschriftentitel:
Oncogene
Jahr:
2003
Band / Volume:
22
Heft / Issue:
36
Seitenangaben Beitrag:
5646-57
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1206673
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12944913
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Humangenetik
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