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Titel:

Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ari, F; Napieralski, R; Ulukaya, E; Dere, E; Colling, C; Honert, K; Kruger, A; Kiechle, M; Schmitt, M
Abstract:
Epigenetic drugs are promising add-ons to cancer treatment; still, adverse effects concerning tumour promotion have been reported occasionally. In this in vitro study, we investigated the effect of combination treatment of decitabine with anthracycline-based chemotherapy [5-fluorouracil plus epirubicine plus cyclophosphamide (FEC)] on viability and metastatic activity of breast cancer cell lines, MDA-MB-231 (estrogen receptor-negative) and MCF-7 (estrogen receptor-positive). The effect of decit...     »
Zeitschriftentitel:
Cell Biochem Funct
Jahr:
2011
Band / Volume:
29
Heft / Issue:
8
Seitenangaben Beitrag:
651-9
Sprache:
eng
Volltext / DOI:
doi:10.1002/cbf.1801
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21887697
Print-ISSN:
0263-6484
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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